New research on the role of molecular pore complex in coronavirus replication.

On June 25 a preprint article has been released on coronavirus replication. Using cryo electron microscopy a molecular pore complex was unveiled which would allow export of RNA to the cytosol. A hexameric assembly of a large viral transmembrane protein was found to form the core of the crown-shaped complex. This coronavirus-specific structure likely plays a critical role in coronavirus replication and thus constitutes a novel drug target.


Cryo electron microscopy for this research was performed at NeCEN using our Krios and Aquilos cryo-FIB.


The full article can be found on the BioRxiv website.