Services overview

NeCEN offers a variety of services for users from academia and industry. A general overview is presented on this page. For more information, please follow the links at the right side of this page.


Data Collection

The core service provided by NeCEN to our users is high throughput data collection on two state-of-the-art Titan Krios transmission electron microscopes. These instruments perform cryo-electron microscopy (cryo-EM) in its two most broadly used forms, single particle analysis (SPA) and cryo-electron tomography (cryo-ET). These imaging techniques allow visualization of biomolecular structures, such as proteins, macromolecular complexes, bacteria, and cell organelles at subnanometer resolution in close-to-native conditions (no chemical fixation or staining required).

Sample Preparation

The samples can be prepared at NeCEN or shipped to NeCEN by the customer. We offer rapid plunge freezing and cryo-focused ion beam (cryo-FIB) micromachinery 

Data Processing

Optional services for data processing range from efficient automated movie alignment or tilt series reconstruction to advanced processes like sub-tomogram averaging, initial model building, or map interpretation.

Training and Seminars

NeCEN aims to contribute to the education of a new generation of cryo-electron microscopists by providing training courses (see for example the cryo-EM school).