Understanding Malaria Parasite Sequestration
According to prof. Bram Koster (LUMC), cryo-TEM will offer exciting possibilities in malaria research. During its lifecycle, proteins of the malaria parasite are transported out of the parasite encasing vacuole, through the cytosol of the host cell and anchor into the erythrocyte membrane of red blood cells. Information about the structure of the involved proteins and complexes will enhance the development of molecules that inhibit these proteins, thereby creating new steps in fighting malaria.
